Table 2.

Hospital study variables

Trauma team activation	Data regarding the presence and activation of a trauma team. Also whether a prehospital activation of a massive transfusion protocol is performed.
Emergency department clinical examination	Emergency department clinical assessment including airways, breathing and circulation, estimation of bleeding. Neurological assessment (Glasgow Coma Score, pupils and sensorimotor deficits). Temperature at admission.
Biochemical data	First arterial blood gas performed at hospital admission (pH, PaO2, PaCO2, HCO3, lactate, base excess, haemoglobin). ROTEM (if available). INR value at admission. aPTT value at admission.
Emergency department interventions	Interventions on airways, breathing and circulation including orotracheal intubation or supraglottic device use, use of tourniquets, haemostatic gauzes, pelvic binder, REBOA or resuscitative thoracotomy and positioning of high flow vascular access. In case of REBOA a subset of data will be collected (anatomical zone and duration of balloon inflation). Emergency department fluids and blood products. Total volume of prehospital crystalloids and colloids, units of prehospital packed red blood cells, grams of prehospital fibrinogen, volume of prehospital plasma.
Emergency department diagnostics	Extended Focused Assessment with Sonography for Trauma (if performed and findings). X-Ray (if performed and findings). CT (if performed and findings, date and time of CT).
Emergency department outcomes	Haemodynamic status at disposition from the emergency department (systolic blood pressure, heart rate). Lactate and base excess at emergency department disposal.
Post-emergency department interventions	The patient pathway following disposition from the emergency department is recorded. Patients might be taken into surgery, angiography, intensive care or die. If taken to surgery or angiography details of the procedure and intraoperative findings are recorded. Eventual intraoperative cardiac arrest and return of spontaneous circulation are recorded.
Scores	Injury Severity Score is collected according to international coding standards. Sequential Organ Failure Score at ICU admission. SAPS2 at ICU admission.
Intensive care unit (ICU)/high dependency unit (HDU) admission and discharge	Blood gases at ICU/HDU admission. Blood gases 24 hours from ICU/HDU admission. Organ failures within the first 24 hours of hospital admission. Type and duration of organ support (mechanical ventilation, tracheostomy, vasopressors, renal replacement). Total number of packed red blood cells during first 24 hours (including prehospital transfusion if applicable). Total volume (mL) of plasma during first 24 hours (including prehospital transfusion if applicable). Total number of platelets pool during first 24 hours (including prehospital transfusion if applicable). Total grams of fibrinogen concentrate during first 24 hours (including prehospital transfusion if applicable). Total volume (mL) of crystalloids and colloids during first 24 hours (including prehospital transfusion if applicable). Further organ failures and surgical interventions at 7 days from hospital admission. Further organ failures and surgical interventions at 30 days from hospital admission. Glasgow Outcome Scale Extended 30 days from hospital admission. Date, condition and location of hospital discharge. Primary cause of death.

aPTT, activated Partial Thromboplastin Time; INR, International Normalized Ratio; REBOA, Resuscitative Endovascular Balloon Occlusion of the Aorta; ROTEM, Rotational Thromboelastometry; SAPS2, Simplified Acute Physiology Score 2.