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. 2022 Feb 10;107(6):1374–1383. doi: 10.3324/haematol.2021.279703

Figure 1.

Figure 1.

IVC-ligation-induced deep vein thrombosis in wild-type and Pyk2-knockout mice. Thrombus formation in the inferior vena cava (IVC) was induced by partial vein ligation. Thrombi were extracted 24 or 48 hours (h) after surgery. (A) Incidence of thrombus formation in wild-type (WT) vs. Pyk2-knockout (Pyk2-KO) mice is reported as percentage of the analyzed animals (black bars: mice developing thrombus; white bars: mice with no detectable thrombus). (B) Comparative representative images showing the different size of thrombi from WT and Pyk2-KO mice after 24 hours of IVC ligation. (C and D) Thrombus weight and length at 24 and 48 hours, respectively. **P≤0.01; ***P≤0.005; ****P≤0.001 (17 WT and 31 Pyk2-KO mice were analyzed). (E) Thrombus formation in cross-transfused mice. Pyk2-deficient platelets were re-infused in recipient thrombocytopenic WT mice and WT platelets were re-infused in recipient Pyk2-KO mice (4 animals/group), as indicated. Thrombi were isolated and measured 48 hours upon IVC ligation.