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. 2021 Nov 4;107(6):1311–1322. doi: 10.3324/haematol.2021.278369

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Copyright© 2022 Ferrata Storti Foundation

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Figure 6. — ONO-7475 combination is effective in reducing leukemia burden and promoting mouse survival in xenograf models using a FLT3-ITD AML cell line and a FLT3-ITD AML PDX. MOLM13 luc/gfp cells were injected into NSG mice. After leukemia engraftment, determined by IVIS imaging, mice were treated with vehicle (Tween 80), 10 mg/kg ONO-7475, 100 mg/kg ABT-199 or a combination of both agents. (A) Survival data with median survival (days) is indicated for each group. (B) Measurement of fold change radiance during the course of treatment using IVIS imaging software. (C) Survival data with median survival (days) is indicated for each group. AML PDX model 3028566 cells were injected into NSG mice. After leukemia engraftment determined by flow cytometry for human CD45-positive cells, mice were treated with vehicle (Tween 80), 10 mg/kg ONO-7475, 100 mg/kg ABT-199 or a combination of both agents. (D) Measurement of leukemia burden by measuring CD45-positive cells by flow cytometry during the course of treatment.