Table 3.

Disposition of potential Transfusion-Related Acute Lung Injury (TRALI) inpatient stays and transfusion information ascertained in the Sentinel Distributed Database (SDD)

TRALI case disposition	n= of potential inpatient stays with TRALI as defined with inpatient diagnosis codes (N=195)
Met clinical definition of TRALI* (n=68)
Definitive TRALI	26 (13%)
Possible TRALI	15 (8%)
Delayed TRALI	27 (14%)
Not a case of TRALI (n=127)
Multiple clinical criteria not met and/or other potential diagnoses†	69 (35%)
No evidence of bilateral infiltrates	6 (3%)
Evidence of left atrial hypertension	4 (2%)
Acute Lung Injury not associated with transfusion due to timing‡	36 (18%)
Insufficient information to determine TRALI case disposition§	12 (6%)

^*Clinical criteria included: 1) No evidence of acute lung injury (ALI) prior to transfusion for definitive TRALI, possible and delayed TRALI could have a temporal relationship to an ALI risk factor 2) ALI onset during or within 6 hours of transfusion for definitive TRALI, or onset between 6–72 hours for delayed TRALI 3) Hypoxemia 4) Radiographic evidence of bilateral infiltrates 5) No evidence of left atrial hypertension 6) For definitive TRALI, no temporal relationship to an alternative risk factor for ALI during or within 6 hours of completion of transfusion.

^†Other potential diagnoses included suspected non-transfusion related circulatory overload or pulmonary edema n=21, suspected transfusion related circulatory overload (TACO) n=5 or transfusion related anaphylaxis (TRA) n=7.

^‡Additional potential diagnoses among patients with ALI not associated with a transfusion (due to timing) included TACO (n=9) and non-transfusion related circulatory overload or pulmonary edema (n=12).

^§Reasons for meeting this designation included charts missing critical clinical information (n=11), and inability to rule out TACO with existing information (n=1).