Table 4.

Positive predictive values (PPVs) associated with inpatient diagnosis codes for Transfusion-related acute lung injury (TRALI), Sentinel Distributed Database (SDD)

PPVs associated with inpatient diagnosis codes for TRALI, compared to chart review (N =195)
Stratifications	% (95% Confidence Interval)
Potential-TRALIA,B,C : All TRALI codes below	35% (68/195, 95% CI: 28–42%)
By Potential-TRALIA,B,C recorded in electronic data
Potential-TRALIA: ICD-9-CM code in any position (518.7)	44% (49/111, 95% CI: 35–54%)
Potential-TRALIB: Acute respiratory failure ICD-9-CM code in any position (518.81), WITH code for a blood transfusion reaction (999.80 or 999.89 or E934.7)	24% (19/79, 95% CI: 15–33%)
Potential-TRALIC: Other pulmonary insufficiency (518.82), WITH code for a blood transfusion reaction (999.80 or 999.89 or E934.7)	†
Potential-TRALIB,C (See above)	23% (19/84, 95% CI: 14–33%)
By sex in electronic data
Female	41% (43/106, 95% CI: 31–51%)
Male	28% (25/89, 95% 19–37%)
By age category in electronic data
0–19 years	10% (1/9, 95% CI, 0.3–43%)
20–34 years	32% (6/19, 95% CI: 13–57%)
35–49 years	35% (9/27, 95% CI: 17–54%)
50–64 years	38% (17/45, 95% CI: 24–52%)
65–79 years	39% (22/57, 95% CI: 26–52%)
80+ years	35% (13/37, 95% CI: 20–53%)
By whether any blood transfusion was recorded in electronic data
Transfusion recorded in electronic data	36% (66/182, 95% CI: 29–44%)
No transfusion recorded in electronic data	15% (2/13, 95% CI: 2–45%)
By whether Potential-TRALIA diagnosis code and ‘Principal diagnosis code’ flag was recorded in electronic data
Potential-TRALIA diagnosis code with a ‘Principal diagnosis’ flag recorded in electronic data	44% (4/9, 95% CI: 14–79%)
By whether Potential-TRALIA and ‘Present on admission’ flag was recorded in electronic data
TRALI diagnosis code with a ‘Present on admission’ flag recorded in electronic data	36% (19/53, 95% CI: 23–50%)
By whether mechanical ventilation was recorded in electronic data
Mechanical ventilation recorded in electronic data	39% (44/112, 95% CI: 30–49%)
No Mechanical ventilation recorded in electronic data	29% (24/83, 95% CI: 19–40%)

^*TRALI_A,B,C: TRALI_A, TRALI_B, and TRALI_C;TRALI_A: TRALI, ICD-9-CM code in any position (518.7).

TRALI_B: Acute respiratory failure ICD-9-CM code in any position (518.81), WITH ICD-9-CM code for a blood transfusion reaction (999.80 or 999.89 or E934.7); TRALI_C: Other pulmonary insufficiency (518.82), WITH ICD-9-CM code for a blood transfusion reaction (999.80 or 999.89 or E934.7); TRALI_{B or C}: TRALI_B, or TRALI_C as listed above.

^†0/5 patients meeting potential-TRALIC were confirmed TRALI cases.