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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Nat Rev Endocrinol. 2022 Jun;18(6):327–328. doi: 10.1038/s41574-022-00666-7

Fig. 1 |. Circulating exosomes in metabolic disorders could induce tumour progression.

Fig. 1 |

Metabolic disorders, such as type 2 diabetes mellitus, are characterized by a profile of circulating exosomes (secreted from various cells and tissues) with miRNA cargo distinct from individuals who are metabolically normal. Initial studies suggest that this abnormal miRNA cargo associates with tumour progression, angiogenesis and immune exhaustion. ATMs, adipose tissue macrophages; miRNA, microRNA.