Table 2.
TP53 and MAP2K mutations
| Patient no. | Gene | Mutation | Sequencing depth | VAF | % of B cells | |
|---|---|---|---|---|---|---|
| Variant | Total | |||||
| 4 | TP53 | c.560-1G>A (p.X187_splice) | 54 | 205 | 0.26 | >99 |
| 7 | TP53 | c.154C>T (p.Q52*) | 59 | 59 | 1.00 | >99 |
| 8 | TP53 | c.517G>A (p.V173M) | 47 | 49 | 0.96 | >99 |
| 9 | TP53 | c.659A>G (p.Y220C) | 63 | 130 | 0.48 | >99 |
| 9 | TP53 | c.470T>C (p.V157A) | 40 | 90 | 0.44 | >99 |
| 13 | TP53 | c.672 + 1G>T (p.X224_splice) | 49 | 52 | 0.94 | >99 |
| 3 | MAP2K1 | c.361T>A (p.C121S) | 126 | 323 | 0.39 | 95 |
| 5 | MAP2K1 | c.362G>C (p.C121S) | 72 | 157 | 0.46 | >99 |
| 12 | MAP2K2 | c.170T>G (p.F57C) | 196 | 444 | 0.44 | >99 |
| 14 | MAP2K1 | c.173A>C(p.Q58P) | 20 | 335 | 0.06 | 93 |
| 14 | MAP2K1 | c.308T>A (p.I103N) | 19 | 191 | 0.10 | 93 |
| 15 | MAP2K1 | c.529C>A (p.L177M) | 34 | 65 | 0.52 | >99 |
| 19 | MAP2K1 | c.169A>G (p.K57E) | 46 | 112 | 0.41 | 96 |
The last column is the percentage of HCLv cells relative to total B cells in the sample.