Table 2.

Association between risk factors and overall survival from first progression

Variable	n	HR (95% CI) by univariable analysis	P (HR)	HR (95% CI) by multivariable analysis	P (HR)
Age	452	1.02 (1.01-1.04)	.003	—	—
Stage				—	—
1-3	62	—	—
4	378	1.95 (1.17-3.27)	.010
Splenomegaly				—	—
Yes	210	1.50 (1.07-2.11)	.018
No	157	—	—
LN >5 cm				—	—
Yes	72	0.98 (0.64-1.50)	.928
No	247	—	—
BM involvement				—	—
Yes	315	1.91 (1.15-3.17)	.012
No	59	—	—
Ki67%				—	—
>30	94	1.24 (0.76-2.03)	.384
≤30	93	—	—
CK				—	—
Yes	30	2.21 (1.12-4.36)	.022
No	121	—	—
Blastoid histology				—	—
Yes	61	1.93 (1.28-2.90)	.002
No	245	—	—
Intensive treatment				—	—
Yes	232	1.25 (0.92-1.72)	.157
No	198	—	—
B symptoms
Yes	126	1.41 (1.02-1.96)	.037	1.27 (0.75-2.15)	0.376
No	276	—	—	—	—
MIPI risk score
High risk	67	2.45 (1.38-4.32)	.002	2.14 (1.19-3.85)	0.011
Intermediate risk	72	1.24 (0.67-2.30)	.485	1.24 (0.66-2.33)	0.499
Low risk	74	—	—	—	—
Time to POD
PRF/POD6	65	3.76 (2.46-5.75)	<.001	2.71 (1.42-5.17)	0.002
POD6-24	153	2.12 (1.53-2.93)	<.001	1.33 (0.75-2.35)	0.324
POD>24	237	—	—	—	—

BM, bone marrow; LN, lymph node.