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. 2022 May 30;20:124. doi: 10.1186/s12915-022-01324-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Enriched pathways and gene networks with increased expression in H3K27M cells relative to WT, H3K27me3 peaks, and DNA methylation loss at day 5. A Analysis of H3K27me3 peaks at genes with increased expression in mut vs WT at day 5 reveals an enriched network of genes involved in central nervous system development. B List of genes with H3K27me3 peaks, increased expression in H3K27M cells relative to WT and DNA methylation loss at day 5. C Gene ontology analysis of the genes in B reveals enrichment in pathways involved in brain neoplasms, synapses, and Notch signaling. D A graphical representation of an enriched network of genes related to Notch signaling