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. 2022 May 31;10:82. doi: 10.1186/s40168-022-01271-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Running training changes gut microbial richness and community structure in mice after MI. A Pan analysis for four groups based on genus level (n = 7:18:12:12). B Fecal bacterial community at the phylum level among Sham + control, MI + control, Sham + Run, and MI + Run. C PCoA analysis based on the relative abundance of genus between Sham + control and MI + control groups. D PCoA analysis based on the relative abundance of genus between MI + control and MI + Run groups. E A total of 49 samples were clustered into enterotype 1 (green), enterotype 2 (red), and enterotype 3 (blue) at the genus level. F The percentage of Sham + control, MI + control, Sham + Run, and MI + Run samples distributed in three enterotypes. G Five changed genera among Sham + control, MI + control, Sham + Run, and MI + Run. Significant differences were assessed by ANOSIM analysis in C, D; abund jaccard analysis in E; Wilcoxon rank-sum with FDR in F. *p < 0.05, **p < 0.01, ***p < 0.001