Fig. 6.

3-HPA and 4-HBA protect against cardiac dysfunction after MI. A 3-HPA and 4-HBA increased EF and FS post-MI (n = 10:10:9:11:9:11:11). B 3-HPA and 4-HBA increased endurance capacity post-MI (n = 10:11:10:10:11:11:11). C, D 3-HPA and 4-HBA decreased cardiac ANP and BNP mRNA expression post-MI (n = 6:6:6:6). E 3-HPA and 4-HBA decreased cardiac fibrosis post-MI (n = 7:7:7:7). F 3-HPA and 4-HBA decreased cardiac cross sectional area post-MI by H&E (n = 8:8:8:8). G 3-HPA and 4-HBA decreased cardiac cross sectional area post-MI by WGA (n = 9:9:9:9). H 3-HPA and 4-HBA decreased Bax/Bcl₂, cleaved Caspase3/Caspase3 and Collagen1 post-MI (n = 6:6:6:6). Scale bar: 50 μm in E and 25 μm in F and G. Data were represented as mean ± SD. Significant differences were assessed by one-way ANOVA followed by Bonferroni's multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001