Table 3.

Interval cervical cancer diagnosed between the first and second screening rounds after a negative screen*, by screening test and age group. Includes women with a negative screening test in the English HPV screening pilot’s first round in 2013-16, with information on cervical cancer available until the end of 2018

Age group (years)*	HPV testing	Cytology	HPV testing v cytology (adjusted hazard ratio (95% CI)†
24-49
Total No of woman years	837 960	2 135 315	—
Total No of cervical cancers diagnosed (No of cervical cancers diagnosed per 100 000 woman years)	11 (1.31)	62 (2.90)	0.44 (0.23 to 0.84)
50-59
Total No of woman years	281 369	631 584	—
Total No of cervical cancers diagnosed (No of cervical cancers diagnosed per 100 000 woman years)	2 (0.71)	17 (2.69)	0.26 (0.06 to 1.15)‡
60-64
Total No of woman years	86 712	194 688	—
Total No of cervical cancers diagnosed (No of cervical cancers diagnosed per 100 000 woman years)	1 (1.15)	6 (3.08)	0.39 (0.05 to 3.20)‡

CI=confidence interval; HPV=human papillomavirus.

^*Average numbers of woman years at risk at age 24-49 year were 3.3 years for HPV testing and 3.2 years for cytology; corresponding numbers were 3.8 years and 3.7 years, respectively, at age 50-59 years; and 3.8 years and 3.6 years, respectively, at age 60-64 years.

^†Hazard ratios (for interval cancer diagnosis between first and second screening rounds after a negative screen) were adjusted for age in years, decile of the Index of Multiple Deprivation, and laboratory site. Unadjusted estimates were similar as adjusted estimates and are reported in supplementary table S4.

^‡Unadjusted estimates owing to a small number of cases.