Table 5.

Interval cancer diagnosed between the first and second screening rounds after a negative screen, by type of HPV detection target. Includes women with a negative screening test in the English HPV screening pilot’s first round in 2013-16, with information on cervical cancer available until the end of 2018

After a negative screen for HPV	APTIMA	RealTime	cobas	RealTime or cobas combined	APTIMA v cobas (hazard ratio (95% CI))	RealTime v cobas (hazard ratio (95% CI))	APTIMA v RealTime (hazard ratio (95% CI))	APTIMA v RealTime or cobas combined (hazard ratio (95% CI))
Total No of woman years	143 049	483 578	385 193	868 771	—	—	—	—
Total No of cervical cancers diagnosed (No of cervical cancers diagnosed per 100 000 woman years)	1 (0.70)	4 (0.83)	8 (2.08)	12 (1.38)	0.35 (0.04 to 2.84)*	0.40 (0.12 to 1.33)*	0.73 (0.08 to 6.21)*	0.51 (0.07 to 3.91)*

CI=confidence interval; HPV=high risk human papillomavirus.

^*Unadjusted estimate owing to a small number of cases.