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Pathogenic roles of colony-stimulating factor 1 receptor (CSF1R). A. Tumor-associated macrophages (TAMs); B. Tenosynovial giant cell tumors (TGCTs) with translocation t(1;2) CSF1:COL6A3 with recruitment of CSF1R-expressing cells including macrophages, giant cells, and osteoclasts. C. Histiocytosis (H) with CSF1R Y546_K551 del. D. CSF1R blockade strategies. MAB: monoclonal antibody; TKI: tyrosine kinase inhibitor. Figure created with biorender.com.
