No effects of DIM or 1,4-DHNA on MWM performance. (A) Unstressed mice were examined for their escape latencies in the MWM following 9 weeks of receiving vehicle, DIM or 1,4-DHNA. Two-way repeated ANOVA revealed that there was a main effect of day (F(1,29) = 300.622, p < 0.0001), but no main effect of experimental group (F(2,29) = 0.28, p > 0.05), and no significant interaction between experimental group and day (F(2,29) = 0.056, p > 0.05). (B) Mice subjected to UCMS received daily vehicle, 1,4-DHNA, or 3,7-DHNA beginning 3 weeks prior to UCMS and continued for the entire duration of the experiment. Two-way repeated ANOVA revealed that there was a main effect of day (F(5,140) = 68.151, p < 0.0001), but no main effect of experimental group (F(3,28) = 0.84, p > 0.05), and no significant interaction between experimental group and day (F(15,140) = 0.413, p > 0.05). Results are presented as mean + SEM.