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. Author manuscript; available in PMC: 2022 May 31.
Published in final edited form as: Mol Cancer Res. 2019 Oct 18;18(1):130–139. doi: 10.1158/1541-7786.MCR-19-0451

Figure 4.

Figure 4.

Secreted P. aeruginosa metabolites effects breast cancer cell survival and doxorubicin responsiveness. A. Differential effects of P. aeruginosa conditioned media (P-CM) on MDA-MB-231 human triple negative breast cancer cell, 4T1 murine triple negative breast cancer cell, MCF7 human ER+ breast cancer cell, ZR-75–1 human ER+ breast cancer cell, and 67NR murine ER+ breast cancer cell viability. n=4–6; *p<0.05. B. Combining P-CM and doxorubicin (DOX) enhances anti-cancer chemotherapy effects on MDA-MB-231 human triple negative breast cancer cell, 4T1 murine triple negative breast cancer cell, MCF7 human ER+ breast cancer cell, ZR-75–1 human ER+ breast cancer cell, and 67NR murine ER+ breast cancer cells. n=4; C. Administration of individual P. aeruginosa secreted metabolites pyocyanin, lectin (PA-I), lipopolysaccharide (LPS), exotoxin A, and phospholipase D on MDA-MB-231 cells viability and doxorubicin responsiveness. n=6; *p<0.05.