. Author manuscript; available in PMC: 2022 May 31.

Published in final edited form as: Pharmacol Biochem Behav. 2008 Mar 10;90(2):282–296. doi: 10.1016/j.pbb.2008.03.001

Table 1.

Results of analyses of microdialysates following TBI and their interpretation

Biochemical	Change consequences
Increased glutamate	Hypoxia/ischemia, excitotoxicity
Low glucose	Hypoxia/ischemia; reduced cerebral glucose supply, cerebral glycolysis
Increased lactate	Hypoxia/ischemia
Increased lactate/pyruvate ratio	Hypoxia/ischemia; reduced cellular redox state, reduced cerebral glucose supply, mitochondrial dysfunction
Increased glycerol	Hypoxia, ischemia; cell membrane degradation