Table II.
Dissolution media | Solubility at 37°C (μg/mL) |
---|---|
PBS with 0.5% Tween-80 | 32.5 ± 0.57 |
SGF pH 1.2 | 3.61 ± 0.52 |
FaSGF pH 1.6 | 1.56 ± 0.47 |
FeSGF pH 5.0 | 20.3 ± 0.60 |
SIF pH 6.8 | 3.87 ± 0.26 |
SIF pH 6.8 + pancreatin | 4.86 ± 0.36 |
FaSIF pH 6.5 | 5.59 ± 0.38 |
FaSIF pH 6.5 + pancreatin | 5.93 ± 0.42 |
FeSIF pH 5.8 | 7.02 ± 0.54 |
FeSIF pH 5.8 + pancreatin | 9.04 ± 0.10 |
SGF pH 1.2 + SIF pH 6.8 | 6.43 ± 0.08 |
SGF pH 1.2 + SIF pH 6.8 + pancreatin | 7.88 ± 0.57 |
FaSGF pH 1.6 + FaSIF pH 6.5 | 2.58 ± 0.50 |
FaSGF pH 1.6 + FaSIF pH 6.5 + pancreatin | 4.63 ± 0.27 |
FeSGF pH 5.0 + FeSIF pH 5.8 | 41.3 ± 1.23 |
FeSGF pH 5.0 + FeSIF pH 5.8 + pancreatin | 47.9 ± 0.65 |