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. Author manuscript; available in PMC: 2022 May 31.
Published in final edited form as: AAPS PharmSciTech. 2022 Apr 19;23(5):113. doi: 10.1208/s12249-022-02256-2

Table II.

Solubility of Docetaxel in the Dissolution Media (n=3)

Dissolution media Solubility at 37°C (μg/mL)
PBS with 0.5% Tween-80 32.5 ± 0.57
SGF pH 1.2 3.61 ± 0.52
FaSGF pH 1.6 1.56 ± 0.47
FeSGF pH 5.0 20.3 ± 0.60
SIF pH 6.8 3.87 ± 0.26
SIF pH 6.8 + pancreatin 4.86 ± 0.36
FaSIF pH 6.5 5.59 ± 0.38
FaSIF pH 6.5 + pancreatin 5.93 ± 0.42
FeSIF pH 5.8 7.02 ± 0.54
FeSIF pH 5.8 + pancreatin 9.04 ± 0.10
SGF pH 1.2 + SIF pH 6.8 6.43 ± 0.08
SGF pH 1.2 + SIF pH 6.8 + pancreatin 7.88 ± 0.57
FaSGF pH 1.6 + FaSIF pH 6.5 2.58 ± 0.50
FaSGF pH 1.6 + FaSIF pH 6.5 + pancreatin 4.63 ± 0.27
FeSGF pH 5.0 + FeSIF pH 5.8 41.3 ± 1.23
FeSGF pH 5.0 + FeSIF pH 5.8 + pancreatin 47.9 ± 0.65