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. Author manuscript; available in PMC: 2023 Jan 20.
Published in final edited form as: N Engl J Med. 2021 Nov 13;386(3):252–263. doi: 10.1056/NEJMoa2109794

Figure 2.

Figure 2.

Spline plots for the association of sodium (left), potassium (middle) and sodium-to-potassium ratio (right) with CVD risk

*Hazard ratios were estimated from Cox models stratified by cohort with adjustment for age, sex, race, education attainment, height, body mass index, alcohol consumption, smoking habits, physical activity, history of diabetes and elevated cholesterol status, family history of cardiovascular disease and mutual adjustment for 24-h urinary potassium and sodium excretions. The boxplots demonstrate the distributions of exposure, with lower and upper hinges corresponding to the first and third quartiles. The whiskers extend from the hinge to values no further than 1.5*IQR from the hinge.