. Author manuscript; available in PMC: 2022 Jul 1.

Published in final edited form as: Alzheimers Dement. 2021 Apr 15;17(7):1134–1144. doi: 10.1002/alz.12288

Table 3.

Beat-to-beat SBP complexity and risk of all-cause dementia

	Risk by quintiles of BP complexity						Per SD decrease	P values
	1^st quintile (<0.94)	2^nd quintile (0.94~1.15)	3^rd quintile (1.15~1.38)	4^th quintile (1.38~1.76)	5^th quintile (1.76~3.23)	P for trend	Per SD decrease	P values
Events/Participants at risk	83/367	79/367	63/367	55/367	54/367	-	-	-
HR (Model 1) (95%CI)	1.59 (1.13, 2.24)	1.35 (0.95, 1.91)	1.19 (0.83, 1.71)	1.08 (0.74, 1.57)	1 (reference)	0.003	1.18 (1.06, 1.33)	0.004
HR (Model 2) (95%CI)	1.58 (1.12, 2.22)	1.32 (0.93, 1.88)	1.18 (0.82, 1.70)	1.07 (0.74, 1.56)	1 (reference)	0.004	1.18 (1.05, 1.33)	0.005
HR (Model 3) (95%CI)	1.55 (1.09, 2.20)	1.32 (0.92, 1.88)	1.13 (0.78, 1.63)	1.09 (0.75, 1.60)	1 (reference)	0.007	1.17 (1.04, 1.31)	0.008

Model 1: adjusting for age and sex;

Model 2: further adjustment for mean SBP in addition to model 1;

Model 3: further adjustment for APOE genotype, education, total and HDL cholesterol levels, smoking habits, weight status, history of diabetes and antihypertensive medication use in addition to model 2.