. Author manuscript; available in PMC: 2022 Jul 1.

Published in final edited form as: Alzheimers Dement. 2021 Apr 15;17(7):1134–1144. doi: 10.1002/alz.12288

Table 4.

Beat-to-beat SBP variability and risk of all-cause dementia

	Risk by quintiles of BP complexity						Per SD increase	P values
	1^st quintile (<0.05)	2^nd quintile (0.05~0.06)	3^rd quintile (0.06~0.07)	4^th quintile (0.07~0.09)	5^th quintile (0.09~0.22)	P for trend	Per SD increase	P values
Events/Participants at risk	53/367	60/366	62/367	70/368	89/366	-	-	-
HR (Model 1) (95%CI)	1 (reference)	1.23 (0.85, 1.78)	1.18 (0.81, 1.70)	1.24 (0.87, 1.77)	1.70 (1.21, 2.39)	0.004	1.15 (1.04, 1.27)	0.004
HR (Model 2) (95%CI)	1 (reference)	1.21 (0.84, 1.75)	1.16 (0.80, 1.67)	1.22 (0.85, 1.75)	1.65 (1.18, 2.33)	0.007	1.14 (1.04, 1.26)	0.006
HR (Model 3) (95%CI)	1 (reference)	1.30 (0.90, 1.89)	1.37 (0.94, 1.99)	1.35 (0.94, 1.95)	1.57 (1.11, 2.22)	0.017	1.12 (1.01, 1.23)	0.026

Model 1: adjusting for age and sex;

Model 2: further adjustment for mean SBP in addition to model 1;

Model 3: further adjustment for APOE genotype, education, total and HDL cholesterol levels, smoking habits, weight status, history of diabetes and antihypertensive medication use in addition to model 2.