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. 2022 Apr 25;2022:3846217. doi: 10.1155/2022/3846217

Figure 5.

Figure 5

Lut significantly promotes mitochondrial dysfunction and lipid peroxidation in an iron-dependent manner. Representative images (a) and semiquantitative analyses (b) of JC-1 fluorescence in 786-O cells treated under different conditions (magnification, ×200). (c) Transmission electron microscopy (TEM) observation of mitochondria in OS-RC-2 cells. Representative images (d) and semiquantitative analyses (e) of ROS in 786-O and OS-RC-2 cells treated under different conditions (magnification, ×200). Representative images (f) and semiquantitative analyses (g) of lipid peroxidant in 786-O cells treated under different conditions (magnification, ×200). The data in (b), (e), and (g) are expressed as the mean ± SD. ∗P < 0.05 vs. the NC group, #P < 0.05 vs. Lut group. ROS: reactive oxygen species; Lut: luteolin; DFP: deferiprone; Fer-1: ferrostatin-1.