Figure 9.

Ferroptosis is implicated in the anti-ccRCC mechanisms of Lut in vivo. (a) Expression levels of E-cadherin, MMP2, vimentin, HO-1, and GPX4 of xenograft tumors in each group as determined by western blot. (b) Semiquantitative analyses of band densities in (a). (c) Expression and semiquantification of KI67, E-cadherin, MMP2, vimentin, HO-1, SLC7A11, and GPX4 in xenograft tumors were analyzed by immunohistochemistry (magnification, ×400). The data in (b) and (c) are expressed as the mean ± SD. ^∗P < 0.05 vs. the NC group, ^#P < 0.05 vs. Lut group. Lut: luteolin; DFP: deferiprone; Znpp: zinc protoporphyrin.