. Author manuscript; available in PMC: 2022 May 31.

Published in final edited form as: FEBS J. 2019 Nov 21;287(2):222–238. doi: 10.1111/febs.15127

Table 1. Phosphoinositide roles and localization during autophagy.

An organized list of each phosphoinositide known to be involved in autophagy as illustrated in Figure 2.

Phosphoinositide	Autophagy step	Localization
PI-3-P	Induction Nucleation Fusion Degradation	Omegasome Phagophore Autophagosome Autolysosome
PI-4-P	Induction Elongation & Closure Fusion & Degradation	Plasma membrane Autophagosome Lysosome Autolysosome
PI-5-P	Elongation Fusion	Phagophore Autophagosome
PI-3,5-P₂	Induction Closure & Fusion Degradation	Autophagosome Lysosome Autolysosome
PI-4,5-P₂	Induction Elongation Fusion & Degradation	Plasma membrane Lysosome Autolysosome
PI-3,4,5-P₃	Induction	Plasma membrane