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. 2022 May 18;18(5):e1010231. doi: 10.1371/journal.ppat.1010231

Fig 3. Microglia respond to RVFV infection in vitro by cytokine secretion and upregulation of activation markers.

Fig 3

Microglia derived from WT or Mavs-/- mice were infected with RVFV MP-12 and at 18–24 h post-infection, cells and cellular supernatants were harvested for flow cytometry and multiplex cytokine analysis, respectively. The expression levels of the indicated activation markers were assessed on uninfected cells (black bars), uninfected cells in culture with infected cells (uninf (w/ inf), gray bars), and infected cells (inf, white bars) and shown as the mean fluorescence intensity of the indicated activation markers (A). Cytokine levels in cellular supernatants (B). Data are shown as the mean +/- SD, nd = not detected and was denoted as zero *p <0.05, **p<0.01, ***p<0.001, ****p<0.0001.