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. 2022 May 31;17(5):e0269261. doi: 10.1371/journal.pone.0269261

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© 2022 Roddy et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — After baseline IOP measurements, three-month-old C57BL/6J mice (n = 26) received a single intracameral injection of ssAAV2-STC-1-FLAG in one eye and ssAAV2-GFP in the fellow eye (1 μL, intracameral injection, 3x10⁹ VGs). After an initial, non-significant decrease in IOP in both ssAAV2-STC-1-FLAG treated mice and ssAAV2-GFP control mice at day 1, and a return to baseline with ssAAV2-GFP by day 2, significant IOP lowering was seen following treatment with ssAAV2-STC-1-FLAG starting at day 2. This IOP reduction persisted until the end of the experiment at day 4.