Fig 3. ssAAV2-STC-1-FLAG reduces IOP in a sustained fashion.
A) After baseline IOP measurements, ssAAV2-STC-1-FLAG was injected in one eye and PBS was injected into the fellow eye of 3-month-old C57BL/6J mice (n = 12, 1 μL, intracameral injection, 3x109 VGs). At the end of experimental week 28, all remaining mice in the study (n = 6) received a second injection. IOP reduction was observed by week one post-injection and this persisted through the end of the experimental period. As IOP lowering began to wane, this was rescued with a repeat injection at week 28. Animals that completed the study were separately designated to demonstrate representative samples. B) Similar data presented in a bar graph format with statistical analysis performed on the average monthly values. *Data where mice had received a second injection.