Fig 6. ssAAV2-STC-1-FLAG reduces IOP in the FP receptor knockout mouse.
A) After baseline IOP measurements, ssAAV2-STC-1-FLAG (3x109 VGs) was injected in one eye and ssAAV2-GFP (3x109 VGs) was injected into the fellow eye (n = 6) of 3-month-old FP receptor knockout mice. IOP lowering was seen in mice treated with intracameral ssAAV2-STC-1-FLAG starting by week 1 post-injection and this persisted through the remainder of the experiment indicating that IOP-lowering is independent of the FP receptor. B) Data presented in a bar graph with statistical analysis performed at week 1, 4, 8, and 14 post-injection.