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. 2022 Jan 10;25(5):412–424. doi: 10.1093/ijnp/pyac004

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© The Author(s) 2022. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Expression of miR-592-3p in the cue-induced incubation of morphine craving. (A) Experimental timeline. (B) Schematics of the in vivo manipulation of the expression of viruses in the NAcC and NAcSh. (C) Schematics of the representative images of the overexpression viruses of miRNA-592-3p in the NAcC (red dots) and NAcSh (black dots). (D) The overexpression of miR-592-3p in the NAcC induced the CPP scores (5 mg/kg morphine conditioned) to decrease on T2 (C: control; AC: rAAV-Decoy miR-592-3p in NAcC; AS: rAAV-Decoy miR-592-3p in NAcSh; VC: vector in NAcC; VS: vector in NAcSh). ***P < .001 AC vs C, AC vs VS; **P < .01 AC vs AS, AC vs VC. (E) Schematics of the representative images of the knockdown viruses of miRNA-592-3p in the NAcC (red dots) and NAcSh (black dots). (F) Downregulation of miR-592-3p in the NAcC induced the CPP scores (1 mg/kg morphine conditioned) increased on T2. **P < .01 vs VS; *P < .05 vs C.