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. 2021 Dec 11;25(5):361–374. doi: 10.1093/ijnp/pyab091

Figure 1.

Figure 1.

Comparison of GMV in olfactory-related regions among the AD, MCI, SCD, and NC groups. The olfactory-related regions were defined as the ROI, including the piriform cortex, amygdala, entorhinal cortex, orbitofrontal cortex, hippocampus, parahippocampus, thalamus, insula, caudate nucleus, putamen, fusiform gyrus, temporal pole, and gyrus rectus. Across the 4 groups, significant differences in GMV were found in the bilateral orbital frontal cortex, temporal pole, hippocampus, parahippocampus, insula, fusiform gyrus, amygdala, caudate nucleus, putamen, rectus, entorhinal cortex, thalamus, and piriform cortex. More details of the comparison are listed in Table 2. Multiple comparison correction was performed using a false discovery rate at P < .05. The color scale bar shows the logarithmic scale of P values (-log10). The closer to yellow or light blue, the more significant the difference between groups. Abbreviations: AD, Alzheimer’s disease; ANCOVA, analysis of covariance; GMV, grey matter volume, MCI, mild cognitive impairment; NC, normal control; SCD, subjective cognitive decline.