Table 1.
Baseline characteristics of patients and healthy control participants.
| Variable | Patients | Healthy control participants | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (n = 10) | Mean | SD | Min | Q1 | Median | Q3 | Max | (n = 10) | Mean | SD | Min | Q1 | Median | Q3 | Max | |
| Age, years | 61.1 | 7.5 | 45 | 56 | 64 | 67 | 70 | 59.5 | 8.8 | 40 | 54 | 59.5 | 67 | 71 | ||
| Sex, males, no. (%) | 7(70) | 7(70) | ||||||||||||||
| Race, Caucasian, no. (%) | 10(100) | 10(100) | ||||||||||||||
| DSA | 1(10) | |||||||||||||||
| Education levels, no. (%) | ||||||||||||||||
| Unskilled worker | 0 | 0 | ||||||||||||||
| Semi-skilled | 0 | 0 | ||||||||||||||
| Skilled worker | 6(60) | 5(50) | ||||||||||||||
| Bachelor | 1(10) | 1(10) | ||||||||||||||
| Master | 3(30) | 4(40) | ||||||||||||||
| DMSO high, no. (%) | 5(50) | |||||||||||||||
| Treatment over 2 days, no. (%) | 4(40) | |||||||||||||||
| Whole saliva flow rates mL/minute | ||||||||||||||||
| Unstimulated whole saliva flow rate | 0.13 | 0.06 | 0.1 | 0.1 | 0.1 | 0.2 | 0.2 | 0.451 | 0.20 | 0.2 | 0.3 | 0.4 | 0.5 | 0.8 | ||
| Stimulated whole saliva flow rate | 0.66 | 0.34 | 0.1 | 0.4 | 0.7 | 0.9 | 1.1 | 2.439 | 1.06 | 0.9 | 1.7 | 2.5 | 3.2 | 4.0 | ||
| XQ summary score | 53.5 | 23.2 | 12.5 | 39.4 | 62.5 | 68.8 | 81.3 | 3.125 | 5.63 | 0.0 | 0.3 | 1.3 | 2.5 | 18.8 | ||
| EORTC QLQ-H&N35 (scores 0-100) | ||||||||||||||||
| HNDR | 73.3 | 30.6 | 12.5 | 66.7 | 66.7 | 100 | 100 | |||||||||
| HNSS | 46.7 | 32.2 | 0.0 | 33.3 | 50.0 | 66.7 | 100 | |||||||||
| HNSW | 26.7 | 20.7 | 0.0 | 12.5 | 25.0 | 33.3 | 75 | |||||||||
| Scintigraphic uptake score (scores 0-4) | ||||||||||||||||
| All glands | 1.7 | 0.8 | 0.5 | 1.1 | 1.8 | 2.0 | 3 | |||||||||
| PG | 2.3 | 0.8 | 1.5 | 2.0 | 2.0 | 2.8 | 4 | |||||||||
| SMG | 0.9 | 0.7 | 0.0 | 1.3 | 1.3 | 1.5 | 1.5 | |||||||||
| Scintigraphic excretion fraction, % | ||||||||||||||||
| All glands | 53.3 | 17.0 | 20.3 | 42.0 | 57.7 | 64.8 | 77.7 | |||||||||
| PG | 59.3 | 21.8 | 17.8 | 42.0 | 67.6 | 77.1 | 82.0 | |||||||||
| SMG | 40.3 | 12.1 | 22.8 | 37.0 | 40.4 | 40.9 | 63.1 | |||||||||
| Saliva composition, mmol/L | ||||||||||||||||
| UWS chloride | 21.7 | 8.8 | 13.4 | 17.3 | 18.4 | 25.1 | 42.9 | 17.0 | 2.9 | 13.7 | 14.9 | 16.9 | 17.9 | 24.1 | ||
| SWS chloride | 26.5 | 11.3 | 11.8 | 17.4 | 25.1 | 34.0 | 45.2 | 17.2 | 3.1 | 11.8 | 16.1 | 17.1 | 19.0 | 22.6 | ||
| UWS phosphate | 4.7 | 1.4 | 2.2 | 3.9 | 4.5 | 5.3 | 7.2 | 5.3 | 1.6 | 3.5 | 4.0 | 4.7 | 6.1 | 8.5 | ||
| SWS phosphate | 3.8 | 0.5 | 2.8 | 3.6 | 3.9 | 4.2 | 4.5 | 3.8 | 0.5 | 3.2 | 3.3 | 3.9 | 4.2 | 4.4 | ||
| UWS potassium | 19.1 | 5.0 | 9.7 | 16.6 | 18.3 | 21.9 | 27.2 | 18.4 | 4.2 | 14.6 | 16.2 | 17.6 | 18.4 | 29.6 | ||
| SWS potassium | 19.4 | 3.9 | 13.4 | 16.7 | 18.8 | 22.4 | 26.1 | 17.1 | 2.1 | 14.8 | 15.5 | 16.8 | 18.7 | 20.5 | ||
| UWS sodium | 8.4 | 5.2 | 2.2 | 5.3 | 7.3 | 9.6 | 18.0 | 6.0 | 2.8 | 2.8 | 4.4 | 5.1 | 7.4 | 11.9 | ||
| SWS sodium | 14.7 | 9.9 | 5.5 | 7.0 | 11.2 | 18.1 | 34.0 | 15.0 | 8.7 | 3.4 | 6.1 | 17.2 | 21.9 | 25.4 | ||
| Primary tumor location, no. (%) | ||||||||||||||||
| Tonsil | 10(100) | |||||||||||||||
| Base of tongue | 0(0) | |||||||||||||||
| p16+, no. (%) | 10(100) | |||||||||||||||
| Cancer stage (UICC 8), no. (%) | ||||||||||||||||
| 1 | 7(70) | |||||||||||||||
| 2 | 3(30) | |||||||||||||||
| IMRT + concurrent cisplatin, no. (%) | 10(100) | |||||||||||||||
| Radiation dose SMG | ||||||||||||||||
| Mean Gy right SMG ± SD | 55.5 | 12.9 | 34.8 | 46.4 | 59.9 | 66.1 | 67.6 | |||||||||
| Max Gy right SMG ± SD | 62.0 | 10.6 | 40.2 | 59.1 | 67.7 | 68.5 | 69.6 | |||||||||
| Mean Gy left SMG ± SD | 56.0 | 16.8 | 17.2 | 56.5 | 62.5 | 65.7 | 66.9 | |||||||||
| Max Gy left SMG ± SD | 58.1 | 17.5 | 25.0 | 51.9 | 68.7 | 69.1 | 69.4 | |||||||||
| Radiation dose PG | ||||||||||||||||
| Mean Gy right PG ± SD | 28.7 | 12.3 | 10.8 | 21.4 | 30.3 | 32.8 | 49.2 | |||||||||
| Max Gy right PG ± SD | 56.8 | 18.4 | 23.5 | 55.0 | 65.3 | 69.3 | 70.8 | |||||||||
| Mean Gy left PG ± SD | 25.6 | 14.0 | 5.4 | 15.1 | 26.4 | 31.7 | 49.9 | |||||||||
| Max Gy left PG ± SD | 49.6 | 20.6 | 19.3 | 29.2 | 55.9 | 67.3 | 68.7 | |||||||||
| Smoking status, no. (%) | ||||||||||||||||
| Never smoker | 7(70) | 8(80) | ||||||||||||||
| Previous 0-10 PY | 1(10) | 1(10) | ||||||||||||||
| Previous > 10 PY | 2(20) | 1(10) | ||||||||||||||
| Years from radiation therapy | 5.5 | 2.2 | 2.0 | 4.3 | 5.5 | 6.8 | 9.0 | |||||||||