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. 2022 Apr 18;11(5):478–489. doi: 10.1093/stcltm/szac011

Table 3.

Summary of key secondary outcome measures.

Functional outcomes n Baselinea 120 days follow-upa Difference 95% CI P-value
UWS FR, mL/minute 10 0.13 ± 0.02 0.18 ± 0.02 0.06 0.03 to 0.09 .0009
UWS FR, % change from baseline 10 0 ± 12.4 50.2 ± 12.4 50.2 23.97 to 76.44 .0005
SWS FR, mL/minute 10 0.66 ± 0.11 0.75 ± 0.1 0.09 0.02 to 0.16 .017
SWS FR, % change from baseline 10 0 ± 6.5 20.2 ± 6.5 20.2 5.14 to 35.22 .0099
XQ summary score (0-100) 10 53.5 ± 6.7 30.9 ± 6.7 −22.6 −33.57 to −11.68 .0004
EORTC QLQ-H&N35 (scores 0-100)
 HNDR 10 73.3 ± 7.2 46.7 ± 7.2 −26.7 −46.93 to −6.41 .013
 HNSS 10 46.7 ± 8.3 23.3 ± 8.3 −23.3 −41.52 to −5.15 .015
 HNSW 10 26.7 ± 4.8 16.7 ± 4.8 −10.0 −17.87 to −2.12 .016
Scintigraphic uptake score (scores 0-4)
 All glands 10 1.7 ± 0.2 1.8 ± 0.2 0.1 −0.06 to 0.16 .34
 PG 10 2.3 ± 0.2 2.4 ± 0.2 0.1 −0.06 to 0.16 .34
 SMG 10 0.9 ± 0.2 0.9 ± 0.2 −0.1 −0.16 to 0.06 .34
Scintigraphic excretion fraction, %
 All glands 10 53.3 ± 4.8 55.3 ± 4.8 2.0 −4.75 to 8.76 .52
 PG 10 59.3 ± 6.0 60.8 ± 6.0 1.4 −6.85 to 9.94 .70
 SMG 10 40.3 ± 5.0 44.3 ± 5.0 4.0 −4.16 to 12.06 .28
Saliva composition, mmol/L
 UWS chloride 8 21.7 ± 2.3 19.0 ± 2.4 −2.68 −7.46 to 2.09 .23
 SWS chloride 9 26.5 ± 3.4 25.9 ± 3.4 −0.61 −3.41 to 2.18 .63
 UWS phosphate 8 4.7 ± 0.4 4.4 ± 0.4 −0.28 −1.44 to 0.88 .55
 SWS phosphate 9 3.8 ± 0.2 3.6 ± 0.2 −0.22 −0.88 to 0.44 .47
 UWS potassium 8 19.1 ± 1.4 18.2 ± 1.6 −0.91 −4.57 to 2.74 .54
 SWS potassium 9 19.4 ± 1.1 19.4 ± 1.2 0.02 −2.85 to 2.81 .99
 UWS sodium 8 8.4 ± 1.4 7.2 ± 1.5 −1.17 −3.80 to 1.46 .32
 SWS sodium 9 14.7 ± 3.3 15.7 ± 3.4 1.02 −3.57 to 5.62 .62

Values are least squares means and standard errors, unless otherwise stated.