Key resources table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Commercial assay or kit	Free fatty acid quantification Kit	Sigma-Aldrich	#MAK044
Commercial assay or kit	Triglyceride determination kit	Sigma-Aldrich	#MAK266
Commercial assay or kit	Mouse NGAL (Lipocalin-2) ELISA Kit	BioLegend	#443,707
Chemical compound, drug	T863	MedChemExpress	HY-32219	(30 μM)
Chemical compound, drug	PF 06424439	Bio-Techne	#6348/5	(30 μM)
Chemical compound, drug	Etomoxir	Calbiochem	#236,020	(50 nM; 200 nM)
Chemical compound, drug	Bafilomycin A1	VWR	#J61835.MX	(200 nM)
Chemical compound, drug	CAY10566	MedChemExpress	#HY-15823	(2.5 μM; 5 μM)
Chemical compound, drug	Atglistatin	Sigma-Aldrich	SML1075	(25 μM)
Chemical compound, drug	GSK2606414	MedChemExpress	HY-18072	(5 μM; 10 μM)
Chemical compound, drug	GSK2850163	Sigma-Aldrich	#1,684	(10 μM; 30 μM)
Chemical compound, drug	Ceapin-A7	Sigma-Aldrich	#SML2330	(1 μM; 2 μM)
Chemical compound, drug	Tunicamycin	Sigma-Aldrich	#5045700001	(10 μM)
Chemical compound, drug	Thapsigargin	Sigma-Aldrich	#586,005	(1 μM)
Chemical compound, drug	BODIPY 493/503	Thermo Fisher Scientific	#D3922	(2.5 μg/mL)
Chemical compound, drug	C1-BODIPY 500/510C12	Thermo Fisher Scientific	#D3823	(2 μM)
Chemical compound, drug	C-Laurdan	Dr. B.R. Cho, Korea University, South Korea	PMID:23311388	(10 μg/mL)
Chemical compound, drug	IncuCyte Cytotox Red Reagent	EssenBio	#4632	(1:2000)
Chemical compound, drug	TMRE	Thermo Fisher Scientific	#T669	(50 nM)
Chemical compound, drug	DHE	Thermo Fisher Scientific	#D23107	10 μM
Chemical compound, drug	Streptozotocin; STZ	Sigma-Aldrich	#S0130	(50 mg/kg)
Antibody	Anti-p62 (rabbit, polyclonal)	Cell Signaling	#5114	WB (1:1000)
Antibody	Anti-LC3 (rabbit, polyclonal)	MBL	#PM036	WB (1:1000)
Antibody	Anti-GAPDH (rabbit, polyclonal)	Abcam	#ab9485	WB (1:1000)
Antibody	G anti-KIM-1 (goat, polyclonal)	R&D Systems	#AF1817	IHC (1:100)
Antibody	Anti-SGLT2 (rabbit, polyclonal)	Abcam	#ab85626	IHC (1:200)
Antibody	Anti-p62 (guinea pig, polyclonal)	Progen	#GP62-C	IF (1:1000)
Antibody	Anti-megalin (rabbit, polyclonal)	Prof. Michigami, Osaka Women’s and Children’s Hospital, Osaka, Japan	PMID:15976002	IHC (1:1000)
Cell line (Mus musculus)	iRECs	Prof. Soeren S. Lienkamp. Institute of Anatomy, University of Zurich, Zurich, Switzerland	PMID:27820600
Cell line (Homo sapiens)	HK-2	ATCC	CRL-2190
Cell line (Didelphis marsupialis virginiana)	OK	ATCC	CRL-1840
Sequence-based reagent	18S Fw	This paper	qPCR primers	5′-CGGCTACCACATCCAAGGAA-3′
Sequence-based reagent	18S Rv	This paper	qPCR primers	5′-GCTGGAATTACCGCGGCT-3′
Sequence-based reagent	Actb Fw	This paper	qPCR primers	5′GCTCTGGCTCCTAGCACCAT-3′
Sequence-based reagent	Actb Rv	This paper	qPCR primers	5′-GCCACCGATCCACACAGAGT-3′
Sequence-based reagent	Bip Fw	This paper	qPCR primers	5′-TTCAGCCAATTATCAGCAAACTCT-3′
Sequence-based reagent	Bip Rv	This paper	qPCR primers	5′-TTTTCTGATGTATCCTCTTCACCAGT-3′
Sequence-based reagent	Cd36 Fw	This paper	qPCR primers	5′-GATGACGTGGCAAAGAACAG-3′
Sequence-based reagent	Cd36 Rv	This paper	qPCR primers	5′-TCCTCGGGGTCCTGAGTTAT-3′
Sequence-based reagent	Chop Fw	This paper	qPCR primers	5′-CCACCACACCTGAAAGCAGAA-3′
Sequence-based reagent	Chop Rv	This paper	qPCR primers	5′-AGGTGAAAGGCAGGGACTCA-3′
Sequence-based reagent	Ccl5 Fw	This paper	qPCR primers	5′-CCCTCACCATCATCCTCACT-3′
Sequence-based reagent	Ccl5 Rv	This paper	qPCR primers	5′-TCCTTCGAGTGACAAACACG-3′
Sequence-based reagent	Fn1 Fw	This paper	qPCR primers	5′-TTAAGCTCACATGCCAGTGC-3′
Sequence-based reagent	Fn1 Rv	This paper	qPCR primers	5′-TTAAGCTCACATGCCAGTGC-3′
Sequence-based reagent	Slc27a2 Fw	This paper	qPCR primers	Fw 5′-ACACACCGCAGAAACCAAATGACC-3′
Sequence-based reagent	Slc27a2 Rv	This paper	qPCR primers	5′-TGCCTTCAGTGGATGCGTAGAACT-3′
Sequence-based reagent	s-Xbp1 Fw	This paper	qPCR primers	5′-CTGAGTCCGAATCAGGTGCAG-3′
Sequence-based reagent	s-Xbp1 Rv	This paper	qPCR primers	5′-GTCCATGGGAAGATGTTCTGG-3′
Sequence-based reagent	t-Xbp1 Fw	This paper	qPCR primers	5′-TGGCCGGGTCTGCTGAGTCCG-3′
Sequence-based reagent	t-Xbp1 Rv	This paper	qPCR primers	5′-GTCCATGGGAAGATGTTCTGG-3′