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Endoglycosidase trimming of various antibody glycoforms to core GlcNAc attached to Asn297. Potential substitution of the core GlcNAc with a (1⟶6)-α-fucosyl moiety [▼] does not affect the endoglycosidase efficiency.
Monoclonal antibodies are glycosylated in the CH2 domain with a glycan that can take different forms, such a complex, hybrid or high-mannose. Each glycosylation profile can be trimmed down to the core GlcNAc with a specific endoglycosidase.
