Table 3.
Summary of pharmacokinetic data
| RSA-K57 H4 |
RSA-K92 H2 |
RSA-K92 H3 |
||||
|---|---|---|---|---|---|---|
| Estimate | C. of V. % | Estimate | C. of V. % | Estimate | C. of V. % | |
| 1V1 (ml.kg) | 614 | 6.1 | 371 | 14.0 | 774 | 14.0 |
| 1V2 (ml/kg) | 295 | 16.8 | 440 | 48.1 | 567 | 20.4 |
| 25CL (ml/hr/kg) | 28.2 | 4.5 | 11.4 | 12.5 | 25.7 | 4.7 |
| 25Q (ml/hr/kg) | 8.0 | 27.6 | 7.3 | 42.1 | 280.3 | 77.4 |
| 1T ½ (hrs) | 34 | 8.5 | 54 | 25.0 | 44 | 4.6 |
V1 = Central compartment volume, V2 = peripheral compartment volume, CL = clearance from central compartment, Q = inter-compartmental clearance
25Calculated using 2-compartmental population PK model