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. 2022 May 26;29(1):1684–1697. doi: 10.1080/10717544.2022.2079771

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Overview of the strategies of circumventing the drug efflux in nano drug delivery systems. (i) enhance internalization mediated by NPs (ii) inhibiting P-gp by inhibitors (iii) silencing MDR1 mRNA via RNAi.