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. 2022 May 28;60(1):997–1010. doi: 10.1080/13880209.2022.2067568

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Lupenone increased the protein expression in the skeletal muscle and adipose tissue related to insulin resistance of rats with diabetes. Lupenone increases the protein expression of InsR (A), IRS-1 (B), IRS-2 (C) and GLUT-4 (D) in the skeletal muscle and PPAR-γ (E), IRS-1 (F), IRS-2 (G) and GLUT-4 (H) in the adipose tissue of rats with diabetes. Data are presented as means ± SD. n = 6. *p< 0.05 vs. the T2DM group, ^#p< 0.05 vs. the normal group. SD: standard deviation. K: normal, M: T2DM, Y: rosiglitazone, D: 2.0 mg/kg lupenone, Z: 4.0 mg/kg lupenone, G: 8.0 mg/kg lupenone.