Table 2.
Ventilator and blood gas parameters 1–2 hours prior to and after extubation of infants (N = 140)
| Variable | n (%) | P value | |
|---|---|---|---|
| ES (n = 106) | EF (n = 34) | ||
| Prior to extubation | |||
| Mode of ventilation i.e. SIMV | 68 (64.2) | 20 (58.8) | 0.722* |
| Median RR in breaths/min (IQR) | 30 (10) | 25 (5) | 0.093† |
| Median PIP in cmH2O (IQR) | 15 (1) | 15 (2) | 0.461† |
| Median PEEP in cmH2O (IQR) | 6.0 (0) | 6.0 (0.05) | 0.021† |
| Median Vt in mL/kg (IQR) | 4.9 (3.6) | 4.9 (2.5) | 0.640† |
| Median FiO2 in % (IQR) | 23 (4) | 25 (7.5) | 0.228† |
| Median pH (IQR) | 7.39 (0.08) | 7.38 (0.1) | 0.644† |
| Median pCO2 (IQR) | 37.5 (13.4) | 35.5 (13.9) | 0.513† |
| Median HCO3− (IQR) | 22.4 (3.7) | 21.4 (2.6) | 0.057† |
| Median BE (IQR) | −2.5 (4.8) | −3.3 (4.05) | 0.126† |
| Median Hb in g/dL (IQR) | 13.5 (3.1) | 13.9 (3.6) | 0.363† |
| After extubation | |||
| Respiratory support i.e. CPAP | 77 (72.6) | 28 (82.4) | 0.720* |
| Median pH (IQR) | 7.36 (0.08) | 7.32 (0.13) | <0.001† |
| Median pCO2 (IQR) | 41.2 (1 3.97) | 41.7 (18) | 0.298† |
| Median HCO3− (IQR) | 21.7 (3.4) | 19.6 (2.9) | <0.001† |
| Median BE (IQR) | −3.0 (4.2) | −5.9 (4.4) | <0.001† |
ES = extubation success; EF = extubation failure; SIMV = synchronised intermittent mandatory ventilation; RR = respiratory rate; IQR = interquartile range; PIP = peak inspiratory pressure; PEEP = positive end expiratory pressure; FiO2 = fraction of inspired oxygen; Hb = haemoglobin; HCO3− = bicarbonate; PCO2 = partial pressure of carbon dioxide; Vt = tidal volume.
*
Using Chi-squared test.
†
Using Mann-Whitney U test.