Precision, relative error and extraction efficiency of the seven analytes.
| Analytes | Intra-day (n = 5) | Inter-day (n = 5) | Extraction efficiency | ||||
|---|---|---|---|---|---|---|---|
| Mean ± SD (%) | RE (%) | RSD (%) | Mean ± SD (%) | RE (%) | RSD (%) | ||
| Aripiprazole | 2.7 ± 0.1 | 8.0 | 3.7 | 2.7 ± 0.2 | 8.0 | 7.4 | 51.4 |
| 26.6 ± 2.1 | 6.4 | 7.8 | 27.2 ± 1.8 | 8.8 | 6.6 | 53.8 | |
| 48.6 ± 5.4 | 8.0 | 11.1 | 49.4 ± 4.5 | 9.8 | 9.1 | 50.5 | |
| Paliperidone | 2.8 ± 0.1 | 12.0 | 3.6 | 2.7 ± 0.1 | 8.0 | 3.7 | 72.4 |
| 21.6 ± 1.8 | −13.6 | 8.3 | 23.9 ± 3.4 | −4.4 | 14.2 | 78.2 | |
| 37.3 ± 0.9 | −17.1 | 2.4 | 39.7 ± 6.0 | −11.8 | 15.1 | 74.2 | |
| Clozapine | 2.8 ± 0.1 | 12.0 | 3.6 | 2.6 ± 0.2 | 4.0 | 7.7 | 62.9 |
| 24.8 ± 2.0 | −0.8 | 8.1 | 26.0 ± 2.3 | 4.0 | 8.8 | 73.3 | |
| 43.3 ± 0.9 | −3.8 | 2.1 | 43.9 ± 5.9 | −2.4 | 13.4 | 65.4 | |
| Ziprasidone | 2.8 ± 0.1 | 12.0 | 3.6 | 2.8 ± 0.1 | 12.0 | 3.6 | 55.0 |
| 26.5 ± 1.3 | 6.0 | 4.9 | 26.8 ± 1.2 | 7.2 | 4.5 | 66.1 | |
| 47.1 ± 5.1 | 4.7 | 10.8 | 45.1 ± 5.1 | 0.2 | 11.3 | 58.1 | |
| Olanzapine | 2.5 ± 0.1 | 0.0 | 4.0 | 2.4 ± 0.1 | −4.0 | 4.2 | 68.3 |
| 23.6 ± 3.1 | −5.6 | 13.1 | 24.8 ± 3.3 | −0.8 | 13.3 | 70.1 | |
| 37.3 ± 1.3 | −17.1 | 3.5 | 39.4 ± 5.4 | −12.4 | 13.7 | 72.4 | |
| Quetiapine | 2.8 ± 0.1 | 12.0 | 3.6 | 2.7 ± 0.1 | 8.0 | 3.7 | 69.1 |
| 23.3 ± 0.9 | −6.8 | 3.9 | 25.4 ± 2.5 | 1.6 | 9.8 | 68.7 | |
| 40.9 ± 1.0 | −9.1 | 2.4 | 42.3 ± 5.4 | −6.0 | 12.8 | 79.3 | |
| Risperidone | 2.8 ± 0.1 | 12.0 | 3.6 | 2.7 ± 0.1 | 8.0 | 3.7 | 72.3 |
| 24.1 ± 2.6 | −3.6 | 10.8 | 25.4 ± 3.0 | 1.6 | 11.8 | 79.9 | |
| 39.6 ± 1.7 | −12.0 | 4.3 | 43.6 ± 6.9 | −3.1 | 15.8 | 71.5 | |