Figure 1.

Semiquantitative scoring of tau lesion burden. An example of semiquantitative scoring of the different tau lesion types seen with phospho-tau immunostaining using CP13 in cases with PSP and CBD. Pretangles/NFTs, coiled bodies and astrocytic lesions (only tufted astrocytes are shown) were semiquantitatively graded as 1 = mild, 2 = moderate or 3 = severe. Neuropil threads were graded as 1 = low density; 2 = high density or 3 = very high density. Rows show the different tau lesion types. Columns show the increasing severity of pathological lesions. All images are at ×200 magnification. NFT = neurofibrillary tangles