Table 2.
Association of ACR with incident frailty
| Crude models | Adjusted model 1a | Adjusted model 2b | ||||||
|---|---|---|---|---|---|---|---|---|
| ACR | Events, n/N | Incidence rate per 1000 person-years | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Quartiles (mg/g) | ||||||||
| Q1 (<0.73) | 55/278 | 45.3 | Ref | Ref | Ref | |||
| Q2 (0.73–<3.77) | 59/279 | 51.9 | 1.12 (0.77, 1.62) | 0.548 | 1.11 (0.76, 1.65) | 0.585 | 1.12 (0.77, 1.63) | 0.560 |
| Q3 (3.77–<13.43) | 80/279 | 75.3 | 1.79 (1.27, 2.52) | < 0.001 | 1.28 (0.88, 1.86) | 0.203 | 1.33 (0.92, 1.92) | 0.130 |
| Q4 (≥13.43) | 101/279 | 102.9 | 2.57 (1.85, 3.57) | < 0.001 | 1.64 (1.13, 2.37) | 0.009 | 1.48 (1.03, 2.12) | 0.033 |
| P for trend | < 0.001 | 0.005 | 0.021 | |||||
| Categories | ||||||||
| <10 | 172/769 | 54.1 | Ref | Ref | ||||
| 10–<20 | 37/115 | 89.2 | 1.66 (1.16, 2.39) | 0.006 | 1.07 (0.72, 1.61) | 0.729 | 1.12 (0.76, 1.67) | 0.570 |
| 20–<30 | 22/62 | 105.9 | 2.35 (1.50, 3.67) | < 0.001 | 1.37 (0.83, 2.25) | 0.214 | 1.20 (0.70, 2.05) | 0.500 |
| ≥30 | 64/169 | 108.3 | 2.24 (1.68, 2.99) | < 0.001 | 1.61 (1.17, 2.20) | 0.003 | 1.44 (1.06, 1.96) | 0.021 |
aModel 1: adjusted for baseline age, sex, BMI, smoking status, drinking status, residence, educational background, marital status, economic independence status, diabetes, hypertension, estimated glomerular filtration rate, hs-CRP, TG and TC.
bModel 2: using the Fine–Gray competing risk model based on Model 1.