Table 3.

Performance Metrics Based on Validations of the Fitted Multiclass Classifier on Two Test Datasets

Statistics	CON	SCZ	BPAD	MDD
Validation on Test-1
Sensitivity	0.57	0.60	0.49	0.55
Specificity	0.86	0.85	0.87	0.82
Positive Predictive Value (PPV)	0.59	0.55	0.57	0.50
Negative Predictive Value (NPV)	0.85	0.88	0.83	0.85
F1 Score	0.58	0.57	0.52	0.52
Accuracy	0.78	0.80	0.77	0.73
Balanced Accuracy	0.71	0.73	0.68	0.68
Validation on Test-2 a
Sensitivity	0.63	0.58
Specificity	0.60	0.91
Positive Predictive Value (PPV)	0.83	0.67
Neg Predictive Value (NPV)	0.34	0.87
F1 Score	0.71	0.63
Accuracy	0.62	0.83
Balanced Accuracy	0.61	0.75

Note: CON, Healthy Control; SCZ, Schizophrenia; BPAD, Bipolar Affective Disorder; MDD, Major Depressive Disorder. Further details on performance metrics are provided in Supplementary Table 4.

^aThe validation on Test-2 dataset does not have any representation of BPAD and MDD patients.