Table 1.
Antibiotic susceptibilities of methicillin-resistant Staphylococcus aureus isolates from colonized patients in paediatric intensive-care units
| Year | No. of MRSA isolates | Erythromycin (% susceptible) | Gentamicin (% susceptible) | Tetracycline (% susceptible) | TMP/SMX (% susceptible) | Clindamycin (% susceptible) | Inducible clindamycin resistance (%)* |
|---|---|---|---|---|---|---|---|
| 2001 | 21 | 9·5 | 52·4 | 52·4 | 57·1 | 4·8 | 10·0 |
| 2002 | 21 | 9·5 | 76·2 | 66·7 | 91·7† | 25 | 13·3 |
| 2003 | 28 | 3·6 | 100·0 | 96·4 | 100·0† | 11·5 | 26·1 |
| 2004 | 38 | 13·2 | 92·1 | 92·1 | 97·2† | 29·7 | 61·5 |
| 2005 | 26 | 11·5 | 96·2 | 92·3 | 96·0† | 30·8 | 38·9 |
| 2006 | 60 | 11·7 | 100·0 | 96·7 | 100·0 | 35 | 46·2 |
| 2007 | 73 | 8·2 | 98·6 | 91·8 | 95·9 | 28·8 | 48·1 |
| 2008 | 93 | 20·4 | 95·7 | 91·4 | 96·8 | 44·1 | 44·2 |
| 2009 | 91 | 8·8 | 98·9 | 97·8 | 98·9 | 50·6 | 57·8 |
| Total | 451 | 11·8 | 94·5 | 90·9 | 95·4 | 35·1 | 43·0 |
| P value‡ | 0·33 | <0·001 | <0·001 | <0·001 | <0·001 | <0·001 |
*
Proportion of clindamycin-resistant isolates with inducible resistance. Denominators for each year are 20, 16, 23, 26, 18, 39, 52, 52 and 45, respectively.
†
Number of MRSA isolates tested for susceptibility to TMP/SMX was 12 in 2002, four in 2003, 36 in 2004 and 25 in 2005.
‡
P value for trends calculated using the Cochran–Armitage trend test.