Table 1.

Serotype distribution of CNRH* isolates by age and site during the pre- and vaccine era

Isolation site	Age group (years)	Type	Pre-vaccine era (1991–1992)		Early vaccine era (1993–1994)		Late vaccine era (1995–2007)
			n	(%)	n	(%)	n	(%)
CSF	0–15	Type b	164	(96)	95	(84)	69	(50)
		Non-type b
		Type f	1		1		10
		Other	0	(4)	0	(16)	6	(50)
		NT	5		17		52
		Total	170	(100)	113	(100)	137	(100)
	⩾16	Type b	3	(38)	3	(23)	7	(5)
		Non-type b
		Type f	1		1		5
		Other	0	(63)	1	(77)	5	(95)
		NT	4		8		117
		Total	8	(100)	13	(100)	134	(100)
Blood	0–15	Type b	73	(82)	38	(70)	24	(18)
		Non-type b
		Type f	0		0		6
		Other	0	(18)	0	(30)	2	(82)
		NT	16		16		98
		Total	89	(100)	54	(100)	130	(100)
	⩾16	Type b	17	(31)	12	(21)	42	(9)
		Non-type b
		Type f	3		2	(79)	35	(91)
		Other	0	(69)	1		14
		NT	35		43		387
		Total	55	(100)	58	(100)	478	(100)
All invasive	0–15	Type b	237	(92)	133	(80)	93	(35)
		Non-type b
		Type f	1		1		16
		Other	0	(8)	0	(20)	8	(65)
		NT	21		33		150
		Total	259	(100)	167	(100)	267	(100)
	⩾16	Type b	20	(32)	15	(21)	49	(8)
		Non-type b
		Type f	4		3		40
		Other	0	(68)	2	(79)	19	(92)
		NT	39		51		504
		Total	63	(100)	71	(98)	612	(100)

CNRH, National Reference Centre for Haemophilus; CSF, cerebrospinal fluid; NT, non-encapsulated isolates.