Table 1.
Group | MTBC membera | Lineageb | Lineage synonymc | Major spoligotype(s)c | No. | Resistance (%) by resistance type | |||
---|---|---|---|---|---|---|---|---|---|
DS-TB | DR-TB | MDR-TB | XDR-TB | ||||||
A | M. africanum | 5 | West African I | AFRI2 | 2 | 100 | 0 | 0 | 0 |
6 | West African II | AFRI1 | 3 | 100 | 0 | 0 | 0 | ||
M. bovis d | 2 | 0 | 100 | 0 | 0 | ||||
M. bovis BCGe | 1 | 0 | 100 | 0 | 0 | ||||
M. caprae | 1 | 100 | 0 | 0 | 0 | ||||
M. microti | 1 | 100 | 0 | 0 | 0 | ||||
M. pinnipedii | 1 | 100 | 0 | 0 | 0 | ||||
B | M. tuberculosis | 2 | East Asian | Beijing | 63 | 17 | 2 | 51 | 31 |
3 | East African-Indian | CAS | 12 | 92 | 0 | 8 | 0 | ||
4 | Euro-American | Haarlem, LAM, T, X | 113 | 42 | 9 | 36 | 13 | ||
7 | 3 | 100 | 0 | 0 | 0 | ||||
C | M. tuberculosis | 1 | Indo-Oceanic | EAI | 127 | 64 | 10 | 24 | 2 |
D | M. canettii f | 21 | 0 | 100 | 0 | 0 | |||
Probably resistantg | M. tuberculosis | 1 | Indo-Oceanic | EAI | 4 | 100 | 0 | 0 | 0 |
2 | East Asian | Beijing | 2 | 50 | 0 | 50 | 0 |
In accordance with current CLSI guidelines, we considered M. canettii to be part of MTBC, although this classification is disputed.54,55
Based on Coll et al.29
Based on Gagneux & Small.56
Largely intrinsically resistant to pyrazinamide.31
Intrinsically resistant to pyrazinamide and cycloserine.52
Intrinsically resistant to pyrazinamide.31
See Table 2 for more details.