Table 1.
Omadacycline HFS-MAC target versus achieved intrapulmonary concentrations using non-compartmental analyses (NCA)
| Regimen | Dosing frequency | Target Cmax (mg/L) | Target AUC0-24 (mg·h/L) | NCA-based Cmax (mg/L) achieved first 24 h | NCA-based AUC0-24 (mg·h/L) achieved first 24 h | First 24 h AUC/MIC achieved |
|---|---|---|---|---|---|---|
| 1 | Daily | 0.0 | 0.0 | 0 | 0 | 0.00 |
| 2 | Daily | 0.5 | 4.29 | 0.28 | 4.57 | 1.14 |
| 3 | Daily | 1.0 | 8.58 | 1.17 | 15.42 | 3.86 |
| 4 | Daily | 2.0 | 17.15 | 3.15 | 47.08 | 11.77 |
| 5 | Daily | 4.0 | 34.3 | 3.86 | 60.08 | 15.02 |
| 6 | Daily | 8.0 | 68.6 | 8.40 | 125.95 | 31.49 |
| 7 | Daily | 16.0 | 137.2 | 17.96 | 158.20 | 39.55 |
| 8 | Daily | 32.0 | 274.4 | 34.46 | 367.51 | 91.88 |
| 10 +SOC | Daily | 3.0 | 25.76 | 2.20 | 21.54 | 5.39 |
SOC, standard of care.