Table 2.
Omadacycline and combination regimen based γ-slopes and time-to-extinction in the HFS-MAC
| Regimens | Number of observations from HFS replicates | B, initial bacterial load (95% CI) | γ-Kill slope (95% CI) | Time-to-extinction, months (95% credible intervals) |
Adjusted R2 |
|---|---|---|---|---|---|
| R1 | 16 | 4.224 (3.704–4.744) | 0.065 (0.046–0.083) | None | 0.991 |
| R2 | 16 | 4.366 (3.954–4.778) | −0.034 (−0.048 to −0.020) | 9.20 (6.13–13.44) | 0.984 |
| R3 | 16 | 4.303 (3.821–4.785) | −0.027 (−0.043 to −0.012) | 12.72 (7.31–21.00) | 0.978 |
| R4 | 16 | 4.349 (3.882–4.817) | −0.043 (−0.059 to −0.027) | 7.01 (4.37–10.36) | 0.978 |
| R5 | 16 | 4.105 (3.635–4.576) | −0.046 (−0.063 to −0.028) | 6.45 (4.19–9.98) | 0.975 |
| R6 | 16 | 3.973 (3.438–4.508) | −0.046 (−0.067 to −0.026) | 6.22 (4.10–9.27) | 0.966 |
| R7 | 16 | 4.212 (3.756–4.668) | −0.078 (−0.101 to −0.055) | 2.83 (2.19–4.10) | 0.978 |
| R8 | 16 | 4.401 (3.939–4.862) | −0.114 (−0.141 to −0.087) | 2.57 (2.10–3.05) | 0.976 |
| R9 (SOC) | 16 | 4.689 (4.345–5.032) | −0.114 (−0.133 to −0.094) | 2.60 (2.30–2.96) | 0.988 |
| R10 (SOC + omadacycline) | 16 | 4.472 (4.006–4.939) | −0.091 (−0.115 to −0.068) | 3.28 (2.64–4.37) | 0.977 |
r, the growth rate, was used instead of γ-kill slopes for the untreated control arm.