. 2022 Mar 8;77(6):1694–1705. doi: 10.1093/jac/dkac068

Table 3.

Inhibitory sigmoid E_max parameter estimates using two different MAC burden endpoints for each sampling day

	E _con (log₁₀ cfu/mL)		E _max (log₁₀ cfu/mL)		H		EC₅₀ (AUC_0-24/MIC)		EC₈₀ (AUC_0-24/MIC)
Bacterial burden on each sampling day	Mean	95% CI	Mean	95% CI	Mean	95% CI	Mean	95% CI	Mean	95% CI	r ²
Day 3	4.67	4.30–5.02	1.5	1.36–1.64	0.61	0.26–1.49	11.23	0.77–55.69	108.98	7.47–540.46	0.83
Day 5	4.78	4.39–5.14	2.17	1.54–2.80	0.73	0.42–1.24	5.54	1.17–19.8	37.00	7.81–132.25	0.89
Day 7	5.11	4.63–5.55	2.83	2.09–3.17	0.46	0.22–0.83	1.47	0.07–9.29	29.93	1.43–189.17	0.95
Day 10	5.24	4.80–5.64	3.17	2.31–4.03	0.48	0.22–0.92	1.56	0.06–6.88	28.02	1.08–123.56	0.81
Day 14	5.52	4.77–6.21	4.39	3.84–4.94	0.45	0.17–0.83	2.49	0.03–16.36	54.21	0.65–356.20	0.89
Day 21	7.58	6.58–8.45	6.62	4.42–8.82	0.42	0.10–1.17	0.50	<0.01–3.77	13.57	<0.02–102.29	0.92
Day 28	8.41	7.10–9.49	8.41	7.06–9.76	0.47	0.17–0.85	1.37	0.01–8.56	31.99	0.23–199.89	0.92
Burden decline below stasis
Day 3	0.07	0–0.42	−458.80	Imprecise	0.26	0.12–0.88	Imprecise	Imprecise	Imprecise	Imprecise	0.83
Day 5	−0.10	−0.53 to 0.34	−4.40	Imprecise	0.36	0.13–1.04	74.69	Imprecise	3512	283–3.1 × 10⁶	0.89
Day 7	−0.39	−0.86 to 0.08	−6.76	Imprecise	0.19	0.07–0.66	693.00	Imprecise	Imprecise	Imprecise	0.90
Day 10	−0.47	−0.85 to 0.08	−5.28	Imprecise	0.21	0–0.87	27.83	Imprecise	Imprecise	Imprecise	0.95
Day 14	−0.79	0–0.01	−264.50	Imprecise	0.13	0–0.73	Imprecise	Imprecise	Imprecise	Imprecise	0.89
Day 21	−2.91	Imprecise, −1.88	−109.10	Imprecise	0.08	0.03–0.99	Imprecise	Imprecise	Imprecise	Imprecise	0.92
Day 28	−3.89	Imprecise, −2.95	−634.50	Imprecise	0.09	0.05–0.42	Imprecise	Imprecise	Imprecise	Imprecise	0.94