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Monte Carlo simulation population pharmacokinetic parameters in 10 000 subjects
| In subroutine PRIOR | Observed in 10 000 subjects | |||
|---|---|---|---|---|
| Parameter | Median parameter estimate | %CV | Median parameter estimate | %CV |
| Clearance (L/h) | 10.3 | 22.3 | 10.31 | 22.40 |
| Central volume (L) | 21.1 | 94.1 | 21.04 | 95.28 |
| Distributional clearance P1 (L/h) | 101.0 | 65.0 | 100.70 | 65.54 |
| Peripheral Volume 1 (L) | 79.9 | 27.9 | 79.74 | 26.96 |
| Distributional clearance P2 (L/h) | 21.3 | 40 [fixed] | 21.35 | 40.06 |
| Peripheral Volume 2 (L) | 129.0 | 27.5 | 129.10 | 24.40 |
