Figure 1.

Box plots for the area under the concentration-time curve from 0 to 24 hours (AUC₂₄) for rifampicin, isoniazid, pyrazinamide, and ethambutol in children treated for tuberculosis, by weight band. Horizontal reference lines represent target exposures derived from adult studies. For rifampicin, the estimated AUC₂₄ (38.73 mg⋅h/L) was derived from a systematic review and meta-analysis by Stott et al [22]. For isoniazid, pyrazinamide, and ethambutol, 11.6–26.3, 233–429, and 16–28 mg/L represent the respective ranges of the medians from studies in a systematic review by Daskapan et al [23].